Catalytic alcoholysis of epoxides using metal-free cucurbituril-based solids

Metal-free cucurbit[7]uril (CB7) solid-state assemblies promote acid-catalysed alcoholysis of aliphatic and aromatic epoxides under mild conditions to give beta-alkoxy alcohols, which are important intermediates for the synthesis of a vast range of compounds such as bioactive pharmaceuticals. The ca...

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Bibliographic Details
Main Author: Bruno, Sofia M. (author)
Other Authors: Gomes, Ana C. (author), Oliveira, Tania S. M. (author), Antunes, Margarida M. (author), Lopes, Andre D. (author), Valente, Anabela A. (author), Goncalves, Isabel S. (author), Pillinger, Martyn (author)
Format: article
Language:eng
Published: 1000
Subjects:
BETA-ALKOXY ALCOHOLS
SUPRAMOLECULAR CATALYSIS
EFFICIENT CATALYST
ACID CATALYST
OXIDATION
Online Access:http://hdl.handle.net/10773/20273
Country:Portugal
Oai:oai:ria.ua.pt:10773/20273
Description
Summary:Metal-free cucurbit[7]uril (CB7) solid-state assemblies promote acid-catalysed alcoholysis of aliphatic and aromatic epoxides under mild conditions to give beta-alkoxy alcohols, which are important intermediates for the synthesis of a vast range of compounds such as bioactive pharmaceuticals. The catalytic process is heterogeneous and the catalyst can be reused in consecutive runs without any reactivation treatment. The acid species responsible for the catalytic activity of CB7 may be entrapped hydronium ions.

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