Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung

Five years survival of lung cancer is 16%, significantly lower than in prostate (99.9%), breast (88.5%) and colon (64.1%) carcinomas. When diagnosed in the surgical stage it increases to 50% but this group only comprises 14-16% of the cases. DNA methylation has emerged as a potential cancer-specific...

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Bibliographic Details
Main Author: Gomes, A. (author)
Other Authors: Silva, M. Reis (author), Alarcão, A. (author), Couceiro, P. (author), Sousa, V. (author), Carvalho, L. (author)
Format: article
Language:eng
Published: 2014
Subjects:
Adenocarcinoma
Squamous cell carcinoma
Lung
Hypermethylation
MLH1
MSH2
Carcinoma das células escamosas
Pulmão
Hipermetilação
Adaptor Proteins, Signal Transducing
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
DNA Repair
Female
Humans
Lung Neoplasms
Male
Middle Aged
MutL Protein Homolog 1
MutS Homolog 2 Protein
Nuclear Proteins
Retrospective Studies
DNA Methylation
Gene Expression Regulation, Neoplastic
Promoter Regions, Genetic
Online Access:http://hdl.handle.net/10316/102609
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/102609

Internet

http://hdl.handle.net/10316/102609

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