Gene delivery into mesenchymal stem cells: a biomimetic approach using RGD nanoclusters based on poly(amidoamine) dendrimers

Poly(amidoamine) dendrimers (generations 5 and 6) with amine termini were conjugated with peptides containing the arginine-glycine-aspartic acid (RGD) sequence having in view their application as gene delivery vectors. The idea behind the work was to take advantage of the cationic nature of dendrime...

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Bibliographic Details
Main Author: Pandita, Deepti (author)
Other Authors: Santos, José L. (author), Rodrigues, João (author), Pêgo, Ana P. (author), Granja, Pedro L. (author), Tomás, Helena (author)
Format: article
Language:eng
Published: 2019
Subjects:
Animals
Cell survival
Dendrimers
Male
Mesenchymal stem cells
Molecular structure
Nanostructures
Oligopeptides
Polyamines
Rats
Rats, Wistar
Structure-activity relationship
Biomimetics
Gene transfer techniques
.
Faculdade de Ciências Exatas e da Engenharia
Online Access:http://hdl.handle.net/10400.13/2404
Country:Portugal
Oai:oai:digituma.uma.pt:10400.13/2404

Internet

http://hdl.handle.net/10400.13/2404

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