The milk-derived lactoferrin inhibits V-ATPase activity by targeting its V1 domain

Lactoferrin (Lf), a bioactive milk protein, exhibits strong anticancer and antifungal activities. The search for Lf targets and mechanisms of action is of utmost importance to enhance its effective applications. A common feature among Lf-treated cancer and fungal cells is the inhibition of a proton...

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Bibliographic Details
Main Author: Pereira, Cátia Sofia Santos (author)
Other Authors: Rocha, Juliana F. (author), Fernandes, Henrique S. (author), Rodrigues, L. R. (author), Côrte-Real, Manuela (author), Sousa, Sérgio F. (author)
Format: article
Language:eng
Published: 2021
Subjects:
Lactoferrin
V-ATPase
Docking
Molecular dynamics
Ciências Médicas::Biotecnologia Médica
Science & Technology
Online Access:http://hdl.handle.net/1822/73598
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73598

Internet

http://hdl.handle.net/1822/73598

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