New water-soluble Ruthenium(II) cytotoxic complex: biological activity and celular distribution

A novel water soluble organometallic compound, [RuCp(mTPPMSNa)(2,2'-bipy)][CF3SO3] (TM85, where Cp=eta(5)-cyclopentadienyl, mTPPMS = diphenylphosphane-benzene-3-sulfonate and 2,2'-bipy = 2,2'-bipyridine) is presented herein. Studies of interactions with relevant proteins were performe...

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Bibliographic Details
Main Author: Morais, Tânia S. (author)
Other Authors: Santos, Filipa C. (author), Jorge, Tiago F. (author), Côrte-Real, Leonor (author), Madeira, Paulo J. Amorim (author), Marques, Fernanda (author), Robalo, Maria Paula (author), Matos, António (author), Santos, Isabel (author), Garcia, M. Helena (author)
Format: article
Language:eng
Published: 2015
Subjects:
Ruthenium
Cyclopentadienyl
Cytotoxicity
Cellular Uptake
Albumin
Ubiquitin
Online Access:http://hdl.handle.net/10400.21/4953
Country:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/4953

Internet

http://hdl.handle.net/10400.21/4953

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