Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci

Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resu...

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Detalhes bibliográficos
Autor principal: Barros, Patricia (author)
Outros Autores: Amaral, Andreia (author), Abrantes, Leonor (author), Oliveira, Tiago (author), Louro, Henriqueta (author), Silva, Maria joão (author), Jordan, Peter (author), Gama-Carvalho, Margarida (author), Matos, Paulo (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2020
Assuntos:
Colorectal Cancer
BCL6
RAC1
DNA Damage
Vias de Transdução de Sinal e Patologias Associadas
Texto completo:http://hdl.handle.net/10400.18/5797
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5797
Descrição
Resumo:Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resulting from chemoresistance.

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