Molecular mechanisms of the metabolite 4-hydroxytamoxifen of the anticancer drug tamoxifen: use of a model microorganism

A strain of the thermophilic eubacterium Bacillus stearothermophilus was used as a model system to identify membrane mediated cytotoxic effects of 4-hydroxytamoxifen, following previous studies with tamoxifen. With this experimental approach we attempted to further clarify tamoxifen and 4-hydroxytam...

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Detalhes bibliográficos
Autor principal: Monteiro, J. P. (author)
Outros Autores: Martins, J. D. (author), Luxo, P. C. (author), Jurado, A. S. (author), Madeira, V. M. C. (author)
Formato: article
Idioma:eng
Publicado em: 2003
Assuntos:
Texto completo:http://hdl.handle.net/10316/5777
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5777