Particularities of the Hedgehog pathway in acute myeloid leukemia and the role of primary cilia in sensitivity to SMO inhibitors
Leukemic Stem Cells (LSCs) are a population of chemotherapy-resistant cells that appear to be responsible for relapse in acute myeloid leukemia (AML). Dysregulation of the Hedgehog (Hh) pathway appears to be involved in the development and maintenance of these cells. Thus, this pathway has emerged a...
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| Format: | masterThesis |
| Language: | eng |
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2022
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| Online Access: | https://hdl.handle.net/10216/141978 |
| Country: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/141978 |