Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia

PURPOSE. Choroideremia (CHM) is a progressive X-linked degeneration of three ocular layers (photoreceptors, retinal pigment epithelium, and choroid), with a complex and still largely unclear pathogenesis. To investigate the pathophysiology of CHM, the authors engineered mice with a cell type-specifi...

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Bibliographic Details
Main Author: Tolmachova, Tanya (author)
Other Authors: Wavre-Shapton, Silene T. (author), Barnard, Alun R. (author), MacLaren, Robert E. (author), Futter, Clare E. (author), Seabra, Miguel C. (author)
Format: article
Language:eng
Published: 2017
Subjects:
RAB ESCORT PROTEIN-1
LEBERS CONGENITAL AMAUROSIS
PARKINSONS-DISEASE
ZEBRAFISH MODEL
GENE-THERAPY
GTPASES
MICE
ACCUMULATION
MACROPHAGES
MUTATION
Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience
Online Access:https://doi.org/10.1167/iovs.09-4892
Country:Portugal
Oai:oai:run.unl.pt:10362/24047

Internet

https://doi.org/10.1167/iovs.09-4892

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