Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder

Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were fou...

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Bibliographic Details
Main Author: Neto, Susana (author)
Other Authors: Quintela Vieira, Ana Filipa (author), Montezuma, Diana (author), Costa, Natália R. (author), Antunes, Luís (author), Baptista, Tiago (author), Oliveira, Ana Isabel (author), Pinho dos Santos Graça, Maria Inês (author), Rodrigues, Ângelo (author), Magalhães, José S. (author), Oliveira, Jorge (author), Henrique, Rui (author), Jerónimo, Carmen (author)
Format: article
Language:eng
Published: 2019
Subjects:
Urinary Bladder
Aged
RNA
Bladder Neoplasms
Online Access:http://hdl.handle.net/10400.22/12800
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/12800
Description
Summary:Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.

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