Effects of omega-3 and-6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice

We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti - inflammatory, omega-3 lipid eicosapentaenoic acid (. - FCT ; FEDER [POCI/BIA-BCM/55327/2004, SFR...

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Bibliographic Details
Main Author: Jordao, Luisa (author)
Other Authors: Lengeling, Andreas (author), Bordat, Yann (author), Boudou, Frederic (author), Gicquel, Brigitte (author), Neyrolles, Olivier (author), Becker, Pablo D. (author), Guzman, Carlos A. (author), Griffiths, Gareth (author), Anes, Elsa (author)
Format: article
Language:eng
Published: 2015
Subjects:
Immunology
Microbiology
Virology
Online Access:http://hdl.handle.net/10451/21583
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21583
Description
Summary:We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti - inflammatory, omega-3 lipid eicosapentaenoic acid (. - FCT ; FEDER [POCI/BIA-BCM/55327/2004, SFRWBD/14284/2003]. - We thank Cecilia Rodrigues, Maximilliano Gutierrez, Luis Mayorga and Sabrina Marion for their constructive support and discussion. This work was financed by FCT with co-participation of FEDER (POCI/BIA-BCM/55327/2004 and SFRWBD/14284/2003).

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