The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding

PD/BD/114046/2015 SFRH/BD/96189/2013 SFRH/BPD/110640/2015 We thank Gilberto Fronza (from Mutagenesi e Prevenzione Oncologica, Ospedale Policlinico San Martino, Genova, Italy), for providing us with the pLS76 vector. We acknowledge the European Synchrotron Radiation Facility for the provision of sync...

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Bibliographic Details
Main Author: Gomes, Ana Sara (author)
Other Authors: Trovão, Filipa (author), Andrade Pinheiro, Benedita (author), Freire, Filipe (author), Gomes, Sara (author), Oliveira, Carla (author), Domingues, Lucília (author), Romão, Maria João (author), Saraiva, Lucília (author), Carvalho, Ana Luísa (author)
Format: article
Language:eng
Published: 2019
Subjects:
Anticancer therapy
Crystal structure
DNA binding
Mutant p53R280K
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
Online Access:https://doi.org/10.3390/ijms19041184
Country:Portugal
Oai:oai:run.unl.pt:10362/62991

Internet

https://doi.org/10.3390/ijms19041184

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