The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding

PD/BD/114046/2015 SFRH/BD/96189/2013 SFRH/BPD/110640/2015 We thank Gilberto Fronza (from Mutagenesi e Prevenzione Oncologica, Ospedale Policlinico San Martino, Genova, Italy), for providing us with the pLS76 vector. We acknowledge the European Synchrotron Radiation Facility for the provision of sync...

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Detalhes bibliográficos
Autor principal: Gomes, Ana Sara (author)
Outros Autores: Trovão, Filipa (author), Andrade Pinheiro, Benedita (author), Freire, Filipe (author), Gomes, Sara (author), Oliveira, Carla (author), Domingues, Lucília (author), Romão, Maria João (author), Saraiva, Lucília (author), Carvalho, Ana Luísa (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Anticancer therapy
Crystal structure
DNA binding
Mutant p53R280K
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
Texto completo:https://doi.org/10.3390/ijms19041184
País:Portugal
Oai:oai:run.unl.pt:10362/62991
Descrição
Resumo:PD/BD/114046/2015 SFRH/BD/96189/2013 SFRH/BPD/110640/2015 We thank Gilberto Fronza (from Mutagenesi e Prevenzione Oncologica, Ospedale Policlinico San Martino, Genova, Italy), for providing us with the pLS76 vector. We acknowledge the European Synchrotron Radiation Facility for the provision of synchrotron radiation facilities and access to beamline ID30B. This work received financial support from the European Union (FEDER, Fundo Europeu de Desenvolvimento Regional, funds POCI/01/0145/FEDER/007728 through Programa Operacional Factores de Competitividade–COMPETE) and National Funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) under the Partnership Agreement PT2020 UID/MULTI/04378/2013, and projects (3599-PPCDT) PTDC/DTP-FTO/1981/2014–POCI-01-0145-FEDER-016581 and RECI/BBB-BEP/0124/2012. FCT fellowships: PD/BD/114046/2015 (Ana Sara Gomes) and SFRH/BD/96189/2013 (Sara Gomes) (thanks FCT PhD Doctoral Programme BiotechHealth), and SFRH/BPD/110640/2015 (Carla Oliveira).

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