Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice

Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal le...

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Bibliographic Details
Main Author: Cano, Amanda (author)
Other Authors: Ettcheto, Miren (author), Espina, Marta (author), Auladell, Carmen (author), Folch, Jaume (author), Kühne, Britta A (author), Barenys, Marta (author), Sánchez-López, Elena (author), Souto, Eliana B. (author), García, Maria Luisa (author), Turowski, Patric (author), Camins, Antonio (author)
Format: article
Language:eng
Published: 2020
Subjects:
3-nitropropionic acide
pigallocatechin-3-gallate
Huntingtons disease
neurodegenerative diseases
PLGA-PEG
polymeric nanoparticles
3-nitropropionic acid
epigallocatechin-3-gallate
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/74411
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/74411

Internet

http://hdl.handle.net/1822/74411

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