Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a Subchronic In vivo Study

Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5...

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Bibliographic Details
Main Author: Rossato, Luciana G. (author)
Other Authors: Costa, Vera M. (author), Dallegrave, Eliane (author), Arbo, Marcelo (author), Dinis-Oliveira, Ricardo J. (author), Santos-Silva, Alice (author), Duarte, José A. (author), Bastos, Maria de Lourdes (author), Palmeira, C. M. (author), Remião, Fernando (author)
Format: article
Language:eng
Published: 2014
Subjects:
MULTIPLE-SCLEROSIS
PROTEIN-SYNTHESIS
LIVER
HEPATOTOXICITY
CELLS
TOXICITY
PHARMACOKINETICS
CARDIOTOXICITY
CHEMOTHERAPY
INHIBITION
Online Access:http://hdl.handle.net/10316/25490
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/25490

Internet

http://hdl.handle.net/10316/25490

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