HGF Stimulation of Rac1 Signaling Enhances Pharmacological Correction of the Most Prevalent Cystic Fibrosis Mutant F508del-CFTR

Cystic fibrosis (CF), a major life-limiting genetic disease leading to severe respiratory symptoms, is caused by mutations in CF transmembrane conductance regulator (CFTR), a chloride (Cl(-)) channel expressed at the apical membrane of epithelial cells. Absence of functional CFTR from the surface of...

Full description

Bibliographic Details
Main Author: Moniz, Sónia (author)
Other Authors: Sousa, Marisa (author), Moraes, Bruno José (author), Mendes, Ana Isabel (author), Palma, Marta (author), Barreto, Celeste (author), Fragata, José I. (author), Amaral, Margarida D (author), Matos, Paulo (author)
Format: article
Language:eng
Published: 2012
Subjects:
Vias de Transdução de Sinal e Patologias Associadas
Cystic Fibrosis
CFTR
Rac1
Cell Surface
Actin
Online Access:http://hdl.handle.net/10400.18/1131
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/1131

Internet

http://hdl.handle.net/10400.18/1131

Similar Items