TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells

The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. NIS expression in thyroid cancer (TC) cells allows the use of radioactive iodine (RAI) as a diagnostic and therapeutic tool, being RAI therapy the systemic treatment of choice for metasta...

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Bibliographic Details
Main Author: Faria, Márcia (author)
Other Authors: Domingues, Rita (author), Paixão, Francisca (author), Bugalho, Maria João (author), Matos, Paulo (author), Silva, Ana Luísa (author)
Format: article
Language:eng
Published: 2021
Subjects:
Cell Lines
Dose-Response Relationship, Drug
NF-kappa B
Symporters
Thyroid Gland
Tumor Necrosis Factor-alpha
Cancer
Transcriptional Control
Thyroid Carcinoma
Sodium-iodide Symporter
Vias de Transdução de Sinal e Patologias Associadas
Online Access:http://hdl.handle.net/10400.18/7345
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7345

Internet

http://hdl.handle.net/10400.18/7345

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