Abietanes from Plectranthus grandidentatus and P-hereroensis against methicillin- and vancomycin-resistant bacteria
The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active di...
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| Other Authors: | , , , |
| Format: | article |
| Language: | eng |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10451/21347 |
| Country: | Portugal |
| Oai: | oai:repositorio.ul.pt:10451/21347 |
| Summary: | The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7 alpha-acetoxy-6 beta-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98-15.63 mu g/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 mu g/ml were obtained for VRE clinical strains. Some structure-activity relationships are emphasized. (c) 2005 Elsevier GmbH. All rights reserved. |
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