Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage ("shedding") of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The tra...

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Bibliographic Details
Main Author: Cavadas, Miguel (author)
Other Authors: Oikonomidi, Ioanna (author), Gaspar, Catarina J. (author), Burbridge, Emma (author), Badenes, Marina (author), Félix, Inês (author), Bolado, Alfonso (author), Hu, Tianyi (author), Bileck, Andrea (author), Gerner, Christopher (author), Domingos, Pedro M. (author), von Kriegsheim, Alex (author), Adrain, Colin (author)
Format: article
Language:eng
Published: 2019
Subjects:
14-3-3 Proteins
ADAM17 Protein
Animals
Carrier Proteins
Cell Membrane
Endoplasmic Reticulum
HEK293 Cells
Humans
Mice, Knockout
Mitogen-Activated Protein Kinases
Phosphorylation
Phosphoserine
Signal Transduction
Substrate Specificity
Toll-Like Receptors
Proteolysis
Online Access:http://hdl.handle.net/10400.7/911
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/911

Internet

http://hdl.handle.net/10400.7/911

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