Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B...

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Bibliographic Details
Main Author: Borges, Vítor (author)
Other Authors: Sousa, Carlos (author), Menezes, Luís (author), Gonçalves, António Maia (author), Picão, Miguel (author), Almeida, José Pedro (author), Vieita, Margarida (author), Santos, Rafael (author), Silva, Ana Rita (author), Costa, Mariana (author), Carneiro, Luís (author), Casaca, Pedro (author), Pinto-Leite, Pedro (author), Peralta-Santos, André (author), Isidro, Joana (author), Duarte, Sílvia (author), Vieira, Luís (author), Guiomar, Raquel (author), Silva, Susana (author), Nunes, Baltazar (author), Gomes, João P. (author)
Format: article
Language:eng
Published: 2022
Subjects:
B.1.1.7 Lineage
RT-PCR
SARS-CoV-2
Genome Sequencing
Laboratory Surveillance
Spike Gene Target Failure (SGTF)
Spike Gene Target Late Detection (SGTL)
Infecções Respiratórias
Estados de Saúde e de Doença
Portugal
Online Access:http://hdl.handle.net/10400.18/8056
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/8056
Description
Summary:We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.

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