Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease

Abstract BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, pr...

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Bibliographic Details
Main Author: Feldman, H. (author)
Other Authors: Maia, L. (author), Mackenzie, I. (author), Forster, B. (author), Martzke, J. (author), Woolfenden, A. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Alzheimer disease
cerebral amyloid angiopathy
superficial siderosis
Online Access:http://hdl.handle.net/10400.16/1025
Country:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/1025
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Summary:Abstract BACKGROUND AND PURPOSE: Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD). METHODS: We report a series of 3 AD patients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA. CONCLUSIONS: Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.

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