Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells

Mitochondria function as the powerhouses of the cell for energy conversion through the oxidative phosphorylation process. Accumulation of dysfunctional mitochondria promotes a bioenergetic crisis and cell death by apoptosis. Yeast cells lacking Isc1p, an orthologue of mammalian neutral sphingomyelin...

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Bibliographic Details
Main Author: Teixeira, Vitor (author)
Other Authors: Medeiros, Tânia C. (author), Vilaça, Rita (author), Pereira, Andreia T. (author), Chaves, Susana Alexandra Rodrigues (author), Côrte-Real, Manuela (author), Moradas-Ferreira, Pedro (author), Costa, Vítor (author)
Format: article
Language:eng
Published: 2015
Subjects:
Ceramide
Dnm1p
Isc1p
Mitochondrial dynamics
Mitophagy
Sit4p
Ciências Médicas::Biotecnologia Médica
Science & Technology
Online Access:http://hdl.handle.net/1822/51031
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/51031

Internet

http://hdl.handle.net/1822/51031

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