Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer

Histone variants seem to play a major role in gene expression regulation. In prostate cancer, H2A.Z and its acetylated form are implicated in oncogenes’ upregulation. SIRT1, which may act either as tumor suppressor or oncogene, reduces H2A.Z levels in cardiomyocytes, via proteasome-mediated degradat...

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Bibliographic Details
Main Author: Baptista, Tiago (author)
Other Authors: Pinho dos Santos Graça, Maria Inês (author), Sousa, Elsa Joana (author), Oliveira, Ana Isabel (author), Costa, Natália R. (author), Costa-Pinheiro, Pedro (author), Amado, Francisco (author), Henrique, Rui (author), Jerónimo, Carmen (author)
Format: article
Language:eng
Published: 2014
Subjects:
Prostate cancer
H2A.Z
Sirtuin 1
Epigenetic drugs
Online Access:http://hdl.handle.net/10400.22/3594
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/3594

Internet

http://hdl.handle.net/10400.22/3594

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