Neofiscalin A and fiscalin C are potential novel indole alkaloid alternatives for the treatment of multidrugresistant Gram-positive bacterial infections

Ten indole alkaloids were obtained from the marine sponge-associated fungus Neosartorya siamensis KUFA 0017. We studied the antimicrobial properties of these and of three other compounds previously isolated from the soil fungus N. siamensis KUFC 6349. Only neofiscalin A showed antimicrobial activity...

Full description

Bibliographic Details
Main Author: Bessa L.J. (author)
Other Authors: Buttachon S. (author), Dethoup T. (author), Martins R. (author), Vasconcelos V. (author), Kijjoa A. (author), da Costa P.M. (author)
Format: article
Language:eng
Published: 2016
Subjects:
antiinfective agent
fiscalin C
indole derivative
neofiscalin A
oxacillin
unclassified drug
antibacterial activity
antimicrobial activity
Article
bacterial metabolism
biofilm
brain capillary endothelial cell
controlled study
drug cytotoxicity
drug potentiation
Enterococcus faecalis
fungus isolation
Gram positive infection
human
human cell
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
multidrug resistance
Neosartorya
Neosartorya siamensis
nonhuman
priority journal
soil
sponge (Porifera)
vancomycin resistant Enterococcus
Online Access:https://hdl.handle.net/10216/120281
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120281

Internet

https://hdl.handle.net/10216/120281

Similar Items