BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptors in endosomes. Here, we show that BAD-LAMP (LAMP5) controls TLR9 trafficking to LAMP1+ lat...

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Bibliographic Details
Main Author: Combes, Alexis (author)
Other Authors: Camosseto, Voahirana (author), N'Guessan, Prudence (author), Argüello, Rafael J. (author), Mussard, Julie (author), Caux, Christophe (author), Bendriss-Vermare, Nathalie (author), Pierre, Philippe (author), Gatti, Evelina (author)
Format: article
Language:eng
Published: 2020
Subjects:
Cell Line, Tumor
Cells, Cultured
Dendritic Cells
Endosomes
Humans
Interferon Type I
Lysosomal-Associated Membrane Protein 2
Lysosome-Associated Membrane Glycoproteins
Microscopy, Confocal
NF-kappa B
Protein Transport
RNA Interference
Toll-Like Receptor 9
Transforming Growth Factor beta
Vesicle-Associated Membrane Protein 3
Signal Transduction
Online Access:http://hdl.handle.net/10773/27363
Country:Portugal
Oai:oai:ria.ua.pt:10773/27363

Internet

http://hdl.handle.net/10773/27363

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