Hydrogen peroxide sensing, signaling and regulation of transcription factors

The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed. The complexit...

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Detalhes bibliográficos
Autor principal: Marinho, H. Susana (author)
Outros Autores: Real, Carla (author), Cyrne, Luísa (author), Soares, Helena (author), Antunes, Fernando (author)
Formato: article
Idioma:eng
Publicado em: 2014
Assuntos:
Redox signaling
Localized H2O2 concentrations
Rate constants
Thiol reactivity
Cytosol-nuclear traffic
DNA binding and transactivation
Texto completo:http://hdl.handle.net/10400.21/3303
País:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/3303

Texto Completo

http://hdl.handle.net/10400.21/3303

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