Hydrogen peroxide sensing, signaling and regulation of transcription factors

The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed. The complexit...

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Bibliographic Details
Main Author: Marinho, H. Susana (author)
Other Authors: Real, Carla (author), Cyrne, Luísa (author), Soares, Helena (author), Antunes, Fernando (author)
Format: article
Language:eng
Published: 2014
Subjects:
Redox signaling
Localized H2O2 concentrations
Rate constants
Thiol reactivity
Cytosol-nuclear traffic
DNA binding and transactivation
Online Access:http://hdl.handle.net/10400.21/3303
Country:Portugal
Oai:oai:repositorio.ipl.pt:10400.21/3303

Internet

http://hdl.handle.net/10400.21/3303

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