Two Separate Effects Contribute to Regulatory T Cell Defect in Systemic Lupus Erythematosus Patients and Their Unaffected Relatives

Forkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain]. Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the o...

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Bibliographic Details
Main Author: Costa, N (author)
Other Authors: Marques, O (author), Godinho, SI (author), Carvalho, C (author), Leal, B (author), Figueiredo, AM (author), Vasconcelos, C (author), Marinho, A (author), Moraes-Fontes, MF (author), Gomes da Costa, A (author), Ponte, C (author), Campanilho-Marques, R (author), Cóias, T (author), Martins, AR (author), Viana, JF (author), Lima, M (author), Martins, B (author), Fesel, C (author)
Format: article
Language:eng
Published: 2018
Subjects:
Adult
Aged
Female
Flow Cytometry
Humans
Interleukin-2
Interleukin-2 Receptor alpha Subunit
Leukocyte Common Antigens
Lupus Erythematosus, Systemic
Lymphocyte Activation
Male
Middle Aged
Phenotype
T-Lymphocytes, Regulatory
Up-Regulation
Young Adult
Family
HCC MED
Online Access:http://hdl.handle.net/10400.17/2872
Country:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/2872

Internet

http://hdl.handle.net/10400.17/2872

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