The human mTOR transcript allows cap-independent translation that insures its expression and function during inhibition of global translation

The mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates signals from the cellular nutrient- and energy-status, acting namely on the protein synthesis machinery. Deregulation of mTOR signaling is implicated in major diseases, such as cancer, mainly due to its r...

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Bibliographic Details
Main Author: Marques-Ramos, Ana (author)
Other Authors: Menezes, Juliane (author), Candeias, Marco (author), Willcocks, Mariam (author), Lacerda, Rafaela (author), Teixeira, Alexandre (author), Locker, Nicola (author), Romão, Luísa (author)
Format: conferenceObject
Language:eng
Published: 2025
Subjects:
Genómica Funcional e Estrutural
Expressão Génica
mTOR
Mammalian Target of Rapamycin
Online Access:http://hdl.handle.net/10400.18/4477
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/4477

Internet

http://hdl.handle.net/10400.18/4477

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