Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One...

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Bibliographic Details
Main Author: Carvalho, Filipa S. (author)
Other Authors: Burgeiro, Ana (author), Garcia, Rita (author), Moreno, Antonio J. (author), Carvalho, Rui A. (author), Oliveira, Paulo J. (author)
Format: article
Language:eng
Published: 2013
Subjects:
Doxorubicin
Toxicity
Mitochondria
Cardiac metabolism
Online Access:http://hdl.handle.net/10316/24854
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/24854

Internet

http://hdl.handle.net/10316/24854

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