Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium

The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational...

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Detalhes bibliográficos
Autor principal: Santonen, Tiina (author)
Outros Autores: Alimonti, Alessandro (author), Bocca, Beatrice (author), Duca, Radu Corneliu (author), Galea, Karen S (author), Godderis, Lode (author), Göen, Thomas (author), Gomes, Bruno (author), Hanser, Ogier (author), Iavicoli, Ivo (author), Janasik, Beata (author), Jones, Kate (author), Kiilunen, Mirja (author), Koch, Holger M (author), Leese, Elizabeth (author), Leso, Veruscka (author), Louro, Henriqueta (author), Ndaw, Sophie (author), Porras, Simo P (author), Robert, Alain (author), Ruggieri, Flavia (author), Scheepers, Paul T J (author), Silva, Maria J (author), Viegas, Susana (author), Wasowicz, Wojciech (author), Castano, Argelia (author), Sepai, Ovnair (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Biomonitoring
Human Biomonitoring
Hexavalent chromium
Occupational Exposure
Effect Markers
Electroplating
Exhaled Breath Condensate
Multicenter Study
Welding
Genotoxicidade Ambiental
Texto completo:http://hdl.handle.net/10400.18/6556
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/6556
Descrição
Resumo:The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure to relevant priority chemicals and developing new approaches for occupational biomonitoring. In this manuscript, the hexavalent chromium [Cr(VI)] study design is presented as the first example of this HBM4EU approach. This study involves eight European countries and plans to recruit 400 workers performing Cr(VI) surface treatment e.g. electroplating or stainless steel welding activities. The aim is to collect new data on current occupational exposure to Cr(VI) in Europe and to test new methods for Cr biomonitoring, specifically the analysis of Cr(VI) in exhaled breath condensate (EBC) and Cr in red blood cells (RBC) in addition to traditional urinary total Cr analyses. Furthermore, exposure data will be complemented with early biological effects data, including genetic and epigenetic effects. Personal air samples and wipe samples are collected in parallel to help informing the biomonitoring results. We present standard operational procedures (SOPs) to support the harmonized methodologies for the collection of occupational hygiene and HBM samples in different countries.

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