Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages

Background: Approximately 10 % of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate prol...

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Bibliographic Details
Main Author: Phelan, Jody E. (author)
Other Authors: Coll, Francesc (author), Bergval, Indra (author), Anthony, Richard M. (author), Warren, Rob (author), Sampson, Samantha L. (author), Gey van Pittius, Nicolaas C. (author), Glynn, Judith R. (author), Crampin, Amelia C. (author), Alves, Adriana (author), Bessa, Theolis Barbosa (author), Campino, Susana (author), Dheda, Keertan (author), Grandjean, Louis (author), Hasan, Rumina (author), Hasan, Zahra (author), Miranda, Anabela (author), Moore, David (author), Panaiotov, Stefan (author), Perdigao, Joao (author), Portugal, Isabel (author), Sheen, Patricia (author), de Oliveira Sousa, Erivelton (author), Streicher, Elizabeth M. (author), van Helden, Paul D. (author), Viveiros, Miguel (author), Hibberd, Martin L. (author), Pain, Arnab (author), McNerney, Ruth (author), Clark, Taane G. (author)
Format: article
Language:eng
Published: 2018
Subjects:
POSITIVE SELECTION
LARGE GENOMES
PROTEIN
STRAINS
EVOLUTION
SEQUENCE
INSIGHTS
ASSEMBLIES
DIVERSITY
VIRULENCE
Biotechnology
Genetics
Infectious Diseases
Drug Discovery
SDG 3 - Good Health and Well-being
Online Access:https://doi.org/10.1186/s12864-016-2467-y
Country:Portugal
Oai:oai:run.unl.pt:10362/36612

Internet

https://doi.org/10.1186/s12864-016-2467-y

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