SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Half of human cancers harbor <i>TP53</i> mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. In order to search for mutp53 re...

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Detalhes bibliográficos
Autor principal: Gomes, Sara (author)
Outros Autores: Bosco, Bartolomeo (author), Loureiro, Joana B. (author), Ramos, Helena (author), Raimundo, Liliana (author), Soares, Joana (author), Nazareth, Nair (author), Barcherini, Valentina (author), Domingues, Lucília (author), Oliveira, Carla (author), Bisio, Alessandra (author), Piazza, Silvano (author), Bauer, Matthias R. (author), Brás, João P. (author), Almeida, Maria Inês (author), Gomes, Célia (author), Reis, Flávio (author), Fersht, Alan R. (author), Inga, Alberto (author), Santos, Maria M. M. (author), Saraiva, Lucília (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
anticancer therapeutics
hepatocellular carcinoma
Hsp70
mutant p53
tryptophanol-derived oxazoloisoindolinone
Science & Technology
Texto completo:http://hdl.handle.net/1822/61321
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61321

Texto Completo

http://hdl.handle.net/1822/61321

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