SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Half of human cancers harbor <i>TP53</i> mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. In order to search for mutp53 re...

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Bibliographic Details
Main Author: Gomes, Sara (author)
Other Authors: Bosco, Bartolomeo (author), Loureiro, Joana B. (author), Ramos, Helena (author), Raimundo, Liliana (author), Soares, Joana (author), Nazareth, Nair (author), Barcherini, Valentina (author), Domingues, Lucília (author), Oliveira, Carla (author), Bisio, Alessandra (author), Piazza, Silvano (author), Bauer, Matthias R. (author), Brás, João P. (author), Almeida, Maria Inês (author), Gomes, Célia (author), Reis, Flávio (author), Fersht, Alan R. (author), Inga, Alberto (author), Santos, Maria M. M. (author), Saraiva, Lucília (author)
Format: article
Language:eng
Published: 2019
Subjects:
anticancer therapeutics
hepatocellular carcinoma
Hsp70
mutant p53
tryptophanol-derived oxazoloisoindolinone
Science & Technology
Online Access:http://hdl.handle.net/1822/61321
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61321

Internet

http://hdl.handle.net/1822/61321

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