Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth

The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. Mor...

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Bibliographic Details
Main Author: Silva, Vandeclécio Lira da (author)
Other Authors: Santos, André Mauricio Ribeiro dos (author), Blanco, Wilfredo (author), Souza, Sandro José de (author)
Format: article
Language:eng
Published: 2019
Subjects:
Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
Online Access:https://doi.org/10.1007/s11427-018-9454-7
Country:Brazil
Oai:oai:https://repositorio.ufrn.br:123456789/26960

Internet

https://doi.org/10.1007/s11427-018-9454-7

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