Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene

Abstract The human C-C chemokine receptor type-5 (CCR5) is the major transmembrane co-receptor that mediates HIV-1 entry into target CD4+ cells. Gene therapy to knock-out the CCR5 gene has shown encouraging results in providing a functional cure for HIV-1 infection. In gene therapy strategies, the i...

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Detalhes bibliográficos
Autor principal: Nerys-Junior,Arildo (author)
Outros Autores: Braga-Dias,Luciene P. (author), Pezzuto,Paula (author), Cotta-de-Almeida,Vinícius (author), Tanuri,Amilcar (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
CCR5
CRISPR-Cas9
efficiency
gene editing
TALEN
Texto completo:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000100167
País:Brasil
Oai:oai:scielo:S1415-47572018000100167

Texto Completo

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000100167

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