Enhancement of solubility of albendazole by complexation with β-cyclodextrin

A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin (β-CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied. In aqueous β-CD, complexati...

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Bibliographic Details
Main Author: Moriwaki,C. (author)
Other Authors: Costa,G. L. (author), Ferracini,C. N. (author), Moraes,F. F. de (author), Zanin,G. M. (author), Pineda,E. A. G. (author), Matioli,G. (author)
Format: article
Language:eng
Published: 2008
Subjects:
Albendazole
Cyclodextrins
β-cyclodextrin
Complexation
Solubility
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200005
Country:Brazil
Oai:oai:scielo:S0104-66322008000200005

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200005

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