Comorbidities increase the risk of severity and mortality in COVID-19 patients: a systematic review and meta-analysis

Introduction: Several studies have shown that patients with comorbidities present a poor clinical outcome of COVID-19, but the conclusions are not yet consolidated. We conducted a meta-analysis to evaluate the relationship between the preexistent conditions (comorbidities) in patients infected with...

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Detalhes bibliográficos
Autor principal: Moura, Edilson Leite de (author)
Outros Autores: Ferreira, Jean Moises (author), Santos , Ana Caroline Melo dos (author), Silva , Denise Macedo da (author), Silva , Maria Lidiane Ferreira da (author), Silva, Gleyce Kelly Marques de Oliveira (author), Silva , Pedro Henrique Nobre (author), Santos, José Anderson dos (author), Barbosa Junior , Marcos Antônio da Silva (author), Lira Neto , Abel Barbosa (author), Silva, Aline Cristine Pereira e (author), Fraga, Carlos Alberto de Carvalho (author), Farias, Karol Fireman de (author), Figueiredo, Elaine Virginia Martins de Souza (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Coronavírus
COVID-19
Comorbidades
Doenças crônicas
SARS-CoV-2.
Coronavirus
Comorbidities
Chronic disease
Comorbilidades
Enfermedades crónicas
Texto completo:https://doi.org/10.33448/rsd-v10i2.12533
País:Brasil
Oai:oai:ojs.pkp.sfu.ca:article/12533
Descrição
Resumo:Introduction: Several studies have shown that patients with comorbidities present a poor clinical outcome of COVID-19, but the conclusions are not yet consolidated. We conducted a meta-analysis to evaluate the relationship between the preexistent conditions (comorbidities) in patients infected with SARS-CoV-2 and the outcome of COVID-19. Methods: PubMed, Science Direct, ISI Web of Science and Scopus databases were examined up to November 2020. We calculated the pooled odds ratio (OR) with 95% confidence interval, using fixed-effects or random-effects models. Results: A total of 48 retrospective cohort studies with 344,290 COVID-19 patients were included in the meta-analysis. The pooled results showed that hypertension, diabetes, cardiovascular, chronic pulmonary, chronic kidney and cerebrovascular diseases increase the risk of severity and mortality in COVID-19 patients. Moreover, malignancy was associated with an increased risk of death from COVID-19. Conclusions: The comorbidities previously mentioned may be important predictors of poor outcome of COVID-19, contributing to the prognosis of severe cases of the disease.

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