Minimal prevalence of Huntington’s disease in the South of Brazil and instability of the expanded CAG tract during intergenerational transmissions

Abstract Huntington’s disease (HD) is due to dominant expansions of the CAG repeat of the HTT gene. Meiotic instability of the (CAG)n might impact the disorder frequency. We report on HD minimal prevalence in Rio Grande do Sul (RS) state, Brazil, and on intergenerational instability of the (CAG)n in...

Full description

Bibliographic Details
Main Author: Castilhos,Raphael Machado de (author)
Other Authors: Santos,José Augusto dos (author), Augustin,Marina Coutinho (author), Pedroso,José Luiz (author), Barsottini,Orlando (author), Saba,Roberta (author), Ferraz,Henrique Ballalai (author), Godeiro Junior,Clécio (author), Vargas,Fernando Regla (author), Salarini,Diego Zanotti (author), Furtado,Gabriel Vasata (author), Polese-Bonatto,Marcia (author), Rodrigues,Luiza Paulsen (author), Sena,Lucas Schenatto (author), Saraiva-Pereira,Maria Luiza (author), Jardim,Laura Bannach (author)
Format: article
Language:eng
Published: 2019
Subjects:
CAG expansion
Huntington’s disease
intergenerational instability
minimal prevalence
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300329
Country:Brazil
Oai:oai:scielo:S1415-47572019000300329

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300329

Similar Items