Anticonvulsant evaluation of 2-pyrazolines carrying naphthyl moiety: An insight into synthesis and molecular docking study

A series of N-substituted-3-(napthalen-2-yl)-5-substituted phenyl-4,5-dihydropyrazole-1-carbothioamide derivatives (4a-n) were synthesized with the view of structural requirements of pharmacophore for potential anticonvulsant agents. The synthesized compounds were assayed intraperitoneally (i.p.) an...

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Bibliographic Details
Main Author: Nusrat, Birjees (author)
Other Authors: Siddiqui, Nadeem (author), Sahu, Meeta (author), Naim, Mohd. Javed (author), ShaharYar, Mohammad (author), Ali, Ruhi (author), Alam, Ozair (author)
Format: article
Language:eng
Published: 2019
Subjects:
Pyrazolines
Anticonvulsants
Molecular docking
Neurotoxicity
Online Access:https://doi.org/10.1590/s2175-97902019000100249
Country:Brazil
Oai:oai:revistas.usp.br:article/164512

Internet

https://doi.org/10.1590/s2175-97902019000100249

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