Effects of lipopolysaccharide on low- and high-density cultured rabbit vascular smooth muscle cells: differential modulation of nitric oxide release, ERK1/ERK2 MAP kinase activity, protein tyrosine phosphatase activity, and DNA synthesis

Previous studies have shown that exogenously generated nitric oxide (NO) inhibits smooth muscle cell proliferation. In the present study, we stimulated rabbit vascular smooth muscle cells (RVSMC) with E. coli lipopolysaccharide (LPS), a known inducer of NO synthase transcription, and established a c...

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Bibliographic Details
Main Author: Oliveira, LCB de (author)
Other Authors: Oliveira, CJR [UNIFESP] (author), Fries, D. M. (author), Stern, A. (author), Monteiro, Hugo Pequeno [UNIFESP] (author)
Format: article
Language:eng
Published: 2018
Subjects:
nitric oxide
lipopolysaccharide
protein tyrosine phosphatases
mitogen-activated protein kinases
DNA synthesis
cell density
Online Access:https://doi.org/http://dx.doi.org/10.1590/S0100-879X2002000200006
https://doi.org/10.1590/S0100-879X2002000200006
Country:Brazil
Oai:oai:k-repositorio.unifesp.br:11600/43127

Internet

https://doi.org/http://dx.doi.org/10.1590/S0100-879X2002000200006
https://doi.org/10.1590/S0100-879X2002000200006

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