Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients

Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood...

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Bibliographic Details
Main Author: Safari-Arababadi,Minoo (author)
Other Authors: Modarressi,Mohammad Hossein (author), Arababadi,Mohammad Kazemi (author)
Format: article
Language:eng
Published: 2019
Subjects:
Innate immunity
hepatitis B
RIP1
IPS-1
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300337
Country:Brazil
Oai:oai:scielo:S1415-47572019000300337
Description
Summary:Abstract IPS-1 and RIP1 are the main downstream molecules of RIG1 and MDA5, as intracytoplasmic receptors, which are the main receptors involved in recognition of internal and external viral double-stranded RNA. In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients. IPS-1 and RIP1 mRNA levels were measured in 60 CHB patients and 120 healthy subjects, using RT-qPCR technique. A significant increase in expression levels of IPS-1 and RIP1 was found in patients when compared to healthy individuals. There was no correlation between IPS-1 and RIP1expression levels with the serum levels of hepatitis B e-Antigen (HBeAg) and liver enzymes in patients. Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.

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