State biomarkers for Machado Joseph disease: Validation, feasibility and responsiveness to change

Abstract Machado-Joseph disease (SCA3/MJD) is the most common spinocerebellar ataxia worldwide, and particularly so in Southern Brazil. Due to an expanded polyglutamine at ataxin-3, SCA3/MJD presents a relentless course with no current disease modifying treatment. Clinical scales used to measure SCA...

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Bibliographic Details
Main Author: Furtado,Gabriel Vasata (author)
Other Authors: Oliveira,Camila Maria de (author), Bolzan,Gabriela (author), Saute,Jonas Alex Morales (author), Saraiva-Pereira,Maria Luiza (author), Jardim,Laura Bannach (author)
Format: article
Language:eng
Published: 2019
Subjects:
Biomarkers
neurophysiology
Machado-Joseph disease
spinocerebellar ataxia type 3
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200238
Country:Brazil
Oai:oai:scielo:S1415-47572019000200238

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200238

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