Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L‑lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...

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Bibliographic Details
Main Author: Fattahi, Ali (author)
Other Authors: Ghiasi, Mansoureh (author), Hosseinzadeh, Leila (author), Adibkia, Khosro (author), Mohammadi, Ghobad (author)
Format: article
Language:eng
Published: 2018
Subjects:
Nanoparticle
PLGA
Flutamide
Prazosin
Prostate cancer
Drug delivery
Online Access:https://doi.org/10.1590/s2175-97902018000417228
Country:Brazil
Oai:oai:revistas.usp.br:article/159202

Internet

https://doi.org/10.1590/s2175-97902018000417228

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