Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L‑lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The struct...

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Detalhes bibliográficos
Autor principal: Fattahi, Ali (author)
Outros Autores: Ghiasi, Mansoureh (author), Hosseinzadeh, Leila (author), Adibkia, Khosro (author), Mohammadi, Ghobad (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
Nanoparticle
PLGA
Flutamide
Prazosin
Prostate cancer
Drug delivery
Texto completo:https://doi.org/10.1590/s2175-97902018000417228
País:Brasil
Oai:oai:revistas.usp.br:article/159202

Texto Completo

https://doi.org/10.1590/s2175-97902018000417228

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