New experimental model of exposure to environmental tobacco smoke

PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals...

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Bibliographic Details
Main Author: Brito,Marcus Vinicius Henriques (author)
Other Authors: Yasojima,Edson Yuzur (author), Silveira,Edvaldo Lima (author), Yamaki,Vitor Nagai (author), Teixeira,Renan Kleber Costa (author), Feijó,Daniel Haber (author), Gonçalves,Thiago Barbosa (author)
Format: article
Language:eng
Published: 2013
Subjects:
Lung Diseases
Smoke Inhalation Injury
Rats
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001200002
Country:Brazil
Oai:oai:scielo:S0102-86502013001200002
Description
Summary:PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological analysis; Experimental Group (EG), that Animals were exposed to the passive smoking; Euthanasia was performed after 14 days of exposure. The serum level of nicotine and histological analysis were performed. RESULTS: There was a statistical difference on the nicotine serum levels between Experimental and Control group, with level of 286 ±23 nanograma/mL in the EG and undetectable on CG (p<0.01). The histological study suggested the model efficacy producing alveolar destruction and emphysema in the EG compared with the insignificant lesions in the CG's lung. CONCLUSION: The model of exposure to environmental tobacco smoke for rodents induced easily the changes related to secondhand smoke.

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