White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive impairment

Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychol...

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Detalhes bibliográficos
Autor principal: Sudo,Felipe Kenji (author)
Outros Autores: Alves,Carlos Eduardo Oliveira (author), Alves,Gilberto Sousa (author), Ericeira-Valente,Letice (author), Tiel,Chan (author), Moreira,Denise Madeira (author), Laks,Jerson (author), Engelhardt,Eliasz (author)
Formato: article
Idioma:eng
Publicado em: 2013
Assuntos:
Texto completo:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700431
País:Brasil
Oai:oai:scielo:S0004-282X2013000700431
Descrição
Resumo:Vascular mild cognitive impairment (VaMCI) represents an early symptomatic stage of vascular cognitive impairment and might be associated to fronto-executive dysfunction.MethodsTwenty-six individuals (age: 73.11±7.90 years; 65.4% female; schooling: 9.84±3.61 years) were selected through neuropsychological assessment and neuroimaging. Clinical and neuroimaging data of VaMCI individuals (n=15) were compared to normal controls (NC, n=11) and correlated with Fazekas scale.ResultsVaMCI performed significantly worse than NC in Trail-Making Test (TMT) B, errors in TMT B, difference TMT B-A and Cambridge Cognitive Examination (CAMCOG) final scores. Correlations were found among scores in modified Fazekas scale and performances in TMT B (time to complete and errors), difference TMT B-A and CAMCOG total score.ConclusionExtension of white matter hyperintensities might be correlated to poorer global cognition and impairments in a set of fronto-executive functions, such as cognitive speed, set shifting and inhibitory control in VaMCI.