Generalized pustular psoriasis (von Zumbusch)

Abstract Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands...

Full description

Bibliographic Details
Main Author: Romiti,Ricardo (author)
Other Authors: Hirayama,André Luís da Silva (author), Arnone,Marcelo (author), Magalhães,Renata Ferreira (author)
Format: article
Language:eng
Published: 2022
Subjects:
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000100063
Country:Brazil
Oai:oai:scielo:S0365-05962022000100063
Description
Summary:Abstract Generalized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences.